The fording spot was settled in 1865, by Ward Keeler. It as initially referred to as Iradell, named by Mr. Keeler, in honor of his son, Ira. A few years later, the community's name was mis-spelled by the town's first Post Master as he registered the community for mail delivery. Through a "government error", the name Iredell has remained the same every since.

Iredell is composed of approximately 360 people inside the city limits and serves as the community hub for a larger population situated in the NE corner of Bosque County. Recently, the discovery of the Barnett Shale formation has been a boon for not only city, but also local land owner's in the vicinity. To what extent this new discovery will effect Iredell's economic development is yet undetermined...but eagerly expected.

Iredell has been the home to several notable people. Clara McDonald Williamson, affectionately known as "Aunt Clara", grew up in Iredell around the turn of the century. Her primitive "memory" paintings of this area are on display in the The Carter Art museum in Fort Worth, TX and the National Art Gallery in Washington, D.C. One of her paintings shows Texas Longhorn cattle crossing the Bosque River near the present bridge site, documenting the Iredell settlement as part of the famous Chisholm Trail.